Amanda Seales was born in Inglewood, California on July 1, 1981.
Her mother was born and raised in Mt. Moritz, Grenada. Her father is African-American. As a result, both she and her mother are dual citizens of the US and Grenada.
She graduated from SUNY-Purchase, then acquired a master's degree in African-American studies with a concentration in Hip hop from Columbia University.
Seales's first film was a minor role as Katy in the 1993 movie Cop and a Half.
On January 26, 2019, HBO debuted her first stand-up comedy special.
In 2007, Seales replaced Natalie Stewart of the musical duo Floetry on tour with Marsha Ambrosius.
Seales hosts a weekly podcast titled Small Doses.
Seales' love of games and music, was used to serve as a safe space for the Black voice and celebrates the many contributions Black Americans have made to history and pop culture and more.
Seales's first book, 'Small Doses: Potent Truths for Everyday Use' was also released in 2019.
As of 2022, Amanda Seales has been living with her boyfriend, Vonnie. The relationship between Seales and her lover is interesting.